NEW YORK — Oct. 1, 2025 — Below are players that can set historic marks or reach career milestones in Week 5 of the 2025 NFL season, including:
- QB Patrick Mahomes
- RB James Cook
- QB Drake Maye
- QB Dak Prescott
- TE Jake Ferguson
- QB Jaxson Dart
- RB Derrick Henry
- WR Puka Nacua
- WR Davante Adams
- WR Justin Jefferson
- DE Myles Garrett
- S Kerby Joseph
PATRICK MAHOMES
Kansas City quarterback Patrick Mahomes recorded four touchdown passes last week and became the fastest player in NFL history (116 regular-season games) to reach 250 career touchdown passes.
Including the postseason, Mahomes has 298 touchdown passes in 137 career games and with two touchdown passes on Monday Night Football at Jacksonville (8:15 p.m. ET, ESPN/ABC), can surpass Aaron Rodgers (147 games) as the fastest player to 300 career touchdown passes, including the postseason, in NFL history.
SUNDAY NIGHT FOOTBALL – JAMES COOK & DRAKE MAYE
The New England Patriots (2-2) visit the Buffalo Bills (4-0) on Sunday Night Football (8:20 p.m. ET, NBC) in Week 5.
Buffalo, from Week 11 of the 2023 season through Week 4 of this season, is the fourth team ever to win 14 consecutive home regular-season games and score at least 24 points in each game, joining the 1997-98 Denver Broncos (15 consecutive home wins), 2017-19 New England Patriots (15) and 2022-23 Dallas Cowboys (14).
Bills running back James Cook is one of four players this season with at least 100 scrimmage yards in each of the first four weeks.
On Sunday night, Cook can become the third player ever with at least 100 scrimmage yards and a rushing touchdown in each of his team’s first five games of a season, joining Pro Football Hall of Famers Jim Brown (first six games with Cleveland in 1958) and O.J. Simpson (first six games with Buffalo in 1975).
New England quarterback Drake Maye, from Weeks 2-4, became the first player ever under the age of 24 with at least two touchdown passes and a completion percentage of 75-or-higher in three consecutive games, minimum 15 pass attempts in each game.
Maye can become the second quarterback in NFL history with a completion percentage of 75-or-higher (minimum 15 attempts in each game) in four consecutive games within a single season, joining Tom Brady (2007 with New England).
Additionally, Maye can become the third quarterback in NFL history with a completion percentage of 75-or-higher (minimum 15 attempts in each game) in six games within his first two career seasons, joining Justin Herbert (six games) and Dak Prescott (six).
DAK PRESCOTT & JAKE FERGUSON
Dallas quarterback Dak Prescott leads the NFL with 121 completions this season, including at least 30 completions in each of his past three games.
With at least 30 completions at the New York Jets on Sunday (1 p.m. ET, FOX), Prescott can become the fourth quarterback ever with at least 30 completions in four consecutive games, joining Tom Brady (five consecutive games in 2022), Kirk Cousins (four in 2018) and Patrick Mahomes (four in 2020).
The players with at least 30 completions in the most consecutive games in NFL history:
| PLAYER | TEAM | SEASON | GAMES |
| Tom Brady | Tampa Bay | 2022 | 5 |
| Kirk Cousins | Minnesota | 2018 | 4 |
| Patrick Mahomes | Kansas City | 2020 | 4 |
| Dak Prescott | Dallas | 2025 | 3* |
| *active streak | |||
Dallas tight end Jake Ferguson leads all tight ends with 34 receptions this season and with six receptions on Sunday, can become the fourth tight end all-time with at least 40 receptions in his team’s first five games of a season, joining Zach Ertz (41 receptions with Philadelphia in 2018), Eric Johnson (41 with San Francisco in 2004) and Pro Football Hall of Famer Antonio Gates (40 with the San Diego Chargers in 2007).
JAXSON DART
New York Giants rookie quarterback Jaxson Dart recorded two touchdowns (one passing, one rushing) in his first career start and win last week.
In Week 5 at New Orleans (1 p.m. ET, CBS), Dart can become the sixth quarterback since 1950 to record both a touchdown pass and rushing touchdown in each of his first two career starts, joining Jake Delhomme (1999), Eric Hipple (1981), Sam Howell (2022-23), Cam Newton (2011) and Tim Tebow (2010).
DERRICK HENRY
Baltimore Ravens running back Derrick Henry enters Week 5 with 109 career rushing touchdowns. With a rushing touchdown on Sunday against Houston (1 p.m. ET, CBS), Henry can tie Pro Football Hall of Famer Walter Payton (110 career rushing touchdowns) for the fifth-most rushing touchdowns in NFL history. Only Pro Football Hall of Famers Emmitt Smith (164 career rushing touchdowns), LaDainian Tomlinson (145) and Marcus Allen (123) as well as Adrian Peterson (120) have more.
The players with the most rushing touchdowns in NFL history:
| PLAYER | TEAM(S) | SEASONS | RUSHING TOUCHDOWNS | |
| Emmitt Smith HOF | Dallas, Arizona | 1990-2004 | 164 | |
| LaDainian Tomlinson HOF | S.D. Chargers, N.Y. Jets | 2001-11 | 145 | |
| Marcus Allen HOF | L.A. Raiders, Kansas City | 1982-97 | 123 | |
| Adrian Peterson | Minnesota, New Orleans, Arizona, Washington, Tennessee, Seattle | 2007-21 | 120 | |
| Walter Payton HOF | Chicago | 1975-87 | 110 | |
| Derrick Henry | Tennessee, Baltimore | 2016-active | 109* | |
| *entering Week 5 | ||||
PUKA NACUA & DAVANTE ADAMS
Los Angeles Rams wide receiver Puka Nacua leads the NFL with 42 receptions this season, tied for the most by a player in his team’s first four games of a season in NFL history.
With eight receptions on Thursday Night Football against San Francisco (8:15 p.m. ET, Prime Video), Nacua can surpass Cooper Kupp (49 receptions in 2022) for the most receptions by a player in his team’s first five games of a season in NFL history.
The players with the most receptions in their team’s first five games of a season in NFL history:
| PLAYER | TEAM | SEASON | RECEPTIONS |
| Cooper Kupp | L.A. Rams | 2022 | 49 |
| T.J. Houshmandzadeh | Cincinnati | 2007 | 47 |
| Adam Thielen | Minnesota | 2018 | 47 |
| Puka Nacua | L.A. Rams | 2025 | 42* |
| *in team’s first four games | |||
Since Week 14 of the 2024 season, Nacua has at least seven receptions in eight straight games and on Thursday, can become the fourth player ever with at least seven receptions in nine consecutive games, joining Antonio Brown (14 consecutive games with Pittsburgh from 2014-15), Cooper Kupp (11 with L.A. Rams in 2021) and Stefon Diggs (nine with Buffalo from 2020-21).
Los Angeles wide receiver Davante Adams has a touchdown reception in three consecutive games this season and in 48 career primetime games (7 p.m. ET start time or later), has 33 touchdown receptions.
With a touchdown reception on Thursday, Adams can tie Pro Football Hall of Famer Terrell Owens (34 touchdown receptions) for the third-most touchdown receptions ever in primetime games (7 p.m. ET start time or later), trailing only Pro Football Hall of Famers Jerry Rice (46) and Randy Moss (44).
The players with the most career touchdown receptions in primetime in NFL history:
| PLAYER | REC. TDs |
| Jerry Rice HOF | 46 |
| Randy Moss HOF | 44 |
| Terrell Owens HOF | 34 |
| Davante Adams | 33 |
JUSTIN JEFFERSON
Since entering the NFL in 2020, Minnesota wide receiver Justin Jefferson has 7,758 receiving yards and 35 career games with at least 100 receiving yards.
With 109 receiving yards on Sunday against Cleveland in London (9:30 a.m. ET, NFL Network), Jefferson can surpass Pro Football Hall of Famers Jerry Rice (7,866 receiving yards) and Calvin Johnson (7,836) for the third-most receiving yards by a player in his first six seasons in NFL history.
The players with the most receiving yards in their first six seasons in NFL history:
| PLAYER | TEAM | REC. YARDS |
| Randy Moss HOF | Minnesota | 8,375 |
| Torry Holt | St. Louis Rams | 8,156 |
| Jerry Rice HOF | San Francisco | 7,866 |
| Calvin Johnson HOF | Detroit | 7,836 |
| Justin Jefferson | Minnesota | 7,758* |
| *in sixth season | ||
On Sunday, Jefferson can also surpass Julio Jones (35 games) for the second-most games with at least 100 receiving yards by a player in his first six seasons in NFL history, trailing only Pro Football Hall of Famer Randy Moss (38 games).
MYLES GARRETT
Cleveland defensive end Myles Garrett leads the NFL with eight tackles for loss and since Week 12 of last season, has at least one tackle for loss in 11 consecutive games.
With a tackle for loss on Sunday against Minnesota in London (9:30 a.m. ET, NFL Network), Garrett can become the fifth player since 2000 with a tackle for loss in 12 consecutive games, joining Robert Quinn (16 consecutive games from 2013-14), J.J. Watt (15 from 2014-15), Pro Football Hall of Famer DeMarcus Ware (13 from 2010-11) and Terrell Suggs (12 in 2010).
The players with the most consecutive games with a tackle for loss since 2000:
| PLAYER | TEAM | SEASON(S) | GAMES |
| Robert Quinn | St. Louis Rams | 2013-14 | 16 |
| J.J. Watt | Houston | 2014-15 | 15 |
| DeMarcus Ware HOF | Dallas | 2010-11 | 13 |
| Terrell Suggs | Baltimore | 2010 | 12 |
| Myles Garrett | Cleveland | 2024-25 | 11* |
| *active streak | |||
Garrett – who has 106.5 career sacks and turns 30 years old on Dec. 29 – can surpass Pro Football Hall of Famer Reggie White (108 sacks) for the most sacks by a player under the age of 30 since 1982, when the individual sack became an official statistic.
KERBY JOSEPH
Detroit safety Kerby Joseph recorded his second interception of the season last week and leads all players with 19 interceptions since entering the NFL in 2022.
With an interception at Cincinnati on Sunday (4:25 p.m. ET, FOX), Joseph can become the sixth player since 2000 with at least 20 interceptions in his first four seasons, joining J.C. Jackson (25 interceptions), Richard Sherman (24), Marcus Peters (22), Pro Football Hall of Famer Ed Reed (22) and Rashean Mathis (20).
The players with the most interceptions in their first four seasons since 2000:
| PLAYER | TEAM(S) | INTERCEPTIONS |
| J.C. Jackson | New England | 25 |
| Richard Sherman | Seattle | 24 |
| Marcus Peters | Kansas City, L.A. Rams | 22 |
| Ed Reed HOF | Baltimore | 22 |
| Rashean Mathis | Jacksonville | 20 |
| Kerby Joseph | Detroit | 19* |
| *in fourth season | ||
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